Preventia: Exercise in the prevention of cognitive impairment in humans

Professor Green and his team’s research continues the theme that they have developed in recent years relating to the impact of haemodynamics, such as shear stress and blood pressure, on adaptations in arteries in humans.  Their work has shown that the impact of exercise training on mortality and cardiovascular events cannot be fully explained on the basis of changes in traditional risk factors. Instead, they have proposed that exercise has direct effects on artery function and structure as a result of changes in lumen flows and pressure.  This work has led to a paradigm shift in Exercise Science.

Professor Green and his team now propose that exercise exerts beneficial effects on cerebrovascular function and cognition in the ageing brain, by virtue of repeated effects on these haemodynamic forces during each exercise bout.  This is an extremely novel idea and the implications are very important in terms of clinical practice and guidelines that evolve to minimise the detrimental impacts of stroke and dementia in Australians.

Collaborator/s

  • Professors Tim Cable and Keith George, ASPIRE Academy and Liverpool John Moores University
  • Professor Nari Kondo, Kobe University
  • Professor Mike Joyner, Mayo Clinic
  • Professor Phil Ainslie, University of British Columbia
  • Professor David Dunstan, Baker IDI
  • Professor Nicola Lautenschlager, University of Melbourne